全文获取类型
收费全文 | 35761篇 |
免费 | 2894篇 |
国内免费 | 2872篇 |
专业分类
耳鼻咽喉 | 429篇 |
儿科学 | 699篇 |
妇产科学 | 259篇 |
基础医学 | 3314篇 |
口腔科学 | 1035篇 |
临床医学 | 2838篇 |
内科学 | 6659篇 |
皮肤病学 | 292篇 |
神经病学 | 1169篇 |
特种医学 | 1259篇 |
外国民族医学 | 1篇 |
外科学 | 4751篇 |
综合类 | 5891篇 |
现状与发展 | 1篇 |
预防医学 | 2348篇 |
眼科学 | 334篇 |
药学 | 3918篇 |
19篇 | |
中国医学 | 1533篇 |
肿瘤学 | 4778篇 |
出版年
2024年 | 25篇 |
2023年 | 426篇 |
2022年 | 759篇 |
2021年 | 1230篇 |
2020年 | 1083篇 |
2019年 | 928篇 |
2018年 | 927篇 |
2017年 | 958篇 |
2016年 | 1209篇 |
2015年 | 1390篇 |
2014年 | 2519篇 |
2013年 | 2745篇 |
2012年 | 2306篇 |
2011年 | 2405篇 |
2010年 | 2036篇 |
2009年 | 1918篇 |
2008年 | 2089篇 |
2007年 | 2044篇 |
2006年 | 1974篇 |
2005年 | 1708篇 |
2004年 | 1289篇 |
2003年 | 1160篇 |
2002年 | 974篇 |
2001年 | 944篇 |
2000年 | 840篇 |
1999年 | 656篇 |
1998年 | 543篇 |
1997年 | 521篇 |
1996年 | 491篇 |
1995年 | 377篇 |
1994年 | 396篇 |
1993年 | 304篇 |
1992年 | 270篇 |
1991年 | 258篇 |
1990年 | 221篇 |
1989年 | 210篇 |
1988年 | 170篇 |
1987年 | 138篇 |
1986年 | 111篇 |
1985年 | 128篇 |
1984年 | 123篇 |
1983年 | 91篇 |
1982年 | 97篇 |
1981年 | 83篇 |
1980年 | 95篇 |
1979年 | 96篇 |
1978年 | 55篇 |
1977年 | 46篇 |
1976年 | 50篇 |
1974年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
1.
2.
【摘要】目的 探讨二维斑点追踪显像技术(2D-STI)评估新生儿窒息合并心肌损害后左心室整体及局部心肌的纵向收缩功能在早期诊断窒息新生儿心肌损害中的临床价值。方法 选择2019年07月至2020年12月期间在右江民族医学院附属医院新生儿科住院的足月窒息新生儿61例,经临床确诊合并心肌损害,根据Apgar评分分为轻度组31例和重度组30例,选择同期住院出生的正常足月新生儿30例作为对照组。检测受检者的血清肌酸激酶同工酶(CK-MB)、肌钙蛋白(cTnT)、左室舒张期前后径(LVDId)、左室射血分数(LVEF)、左室短轴缩短率(LVFS)、辛普森法左室射血分数(Simpson EF)、左室三腔心整体应变(GLS-LAX)、左室四腔心整体应变(GLS-A4C)、左室两腔心整体应变(GLS-A2C)、左室整体应变(GLS-AVG),分析GLS-AVG和CK-MB、cTnT三者的相关性。结果 三组间CK-MB和cTnT比较差异有统计学意义(P<0.05)。三组间性别、体重、胎龄均无统计学差异(P>0.05)。三组间LVDId、LVEF、LVFS、Simpson EF比较差异无统计学意义(P>0.05)。GLS-AVG与CK-MB呈负性相关(r=-0.515,P=0.000),GLS-AVG与cTnT呈负性相关(r=-0.912,P=0.000)。结论 GLS-AVG与CK-MB、cTnT具有相关性,GLS-AVG可作为窒息新生儿心肌损害早期诊断指标。 相似文献
3.
4.
《European journal of surgical oncology》2022,48(8):1778-1784
BackgroundThis study aimed to investigate which gastric cancer patients could benefit the most from staging laparoscopy.MethodsA retrospective cohort study was carried out, including 316 (216 cM- and 100 cM+) gastric cancer patients who had undergone staging laparoscopy between 2010 and 2020 in seven GIRCG centers. A model including easily-accessible clinical, biochemical and pathological markers was constructed to predict the risk of carcinomatosis. ROC curve and decision curve analyses were used to verify its accuracy and net benefit.ResultsIn the cM-population staging laparoscopy could detect 67 cases who had peritoneal carcinomatosis or positive cytology, for a yield of 30.5%. In cM-patients, intestinal type tumors (0.25, 0.12–0.51; p = 0.002), cT4 tumors (2.18, 1.11–4.28; p = 0.023) and cancers of the lower third (0.31, 0.14–0.70; p = 0.004) were associated with the presence of peritoneal carcinomatosis and/or positive cytology. The ROC curve analysis of the model including the three variables showed an AUC of 0.75 (0.68–0.81, p < 0.001). The decision curve analyses showed that the model had a higher net benefit than the treating all strategy between threshold probabilities of 15 and 50%.ConclusionsStaging laparoscopy is a useful tool to address the patient with gastric cancer to the most adequate treatment. In cM-patients the assessment of the location of the tumor, the Lauren's histotype and the cT status may help in providing additional elements in indicating or not the use of staging laparoscopy. 相似文献
5.
6.
《European journal of surgical oncology》2021,47(12):3105-3112
BackgroundDetails of perioperative outcomes and survival after gastric cancer surgery in prior transplant recipients have received minimal research attention.MethodsWe performed an observational cohort study using the database of 20,147 gastric cancer patients who underwent gastrectomy at a single gastric cancer center in Korea. Forty-one solid organ recipients [kidney (n = 35), liver (n = 5), or heart (n = 1)] were matched with 205 controls using propensity score matching.ResultsOperation time, blood loss, and postoperative pain were similar between groups. Short-term complication rates were similar between transplantation and control groups (22.0% vs. 20.1%, P = 0.777). Transplantation group patients with stage 1 gastric cancer experienced no recurrence, while those with stage 2/3 cancer had significantly higher recurrence risk compared to the controls (P = 0.049). For patients with stage 1 cancer, the transplantation group had a significantly higher rate of non-gastric cancer-related deaths compared to the controls (19.2% vs. 1.4%, P = 0.001). For those with stage 2/3 cancer, significantly lower proportion of the transplantation group received adjuvant chemotherapy compared to the control group (26.7% vs. 80.3%, P < 0.001). The transplantation group had a higher (albeit not statistically significant) rate of gastric cancer-related deaths compared to the controls (40.0% vs. 18.0%, P = 0.087).ConclusionTransplant recipients and non-transplant recipients exhibited similar perioperative and short-term outcomes after gastric cancer surgery. From long-term outcome analyses, we suggest active surveillance for non-gastric cancer-related deaths in patients with early gastric cancer, as well as strict oncologic care in patients with advanced cancer, as effective strategies for transplant recipients. 相似文献
7.
Xin-Yu Lin Dan Pan Li-Xuan Sang Bing Chang 《World journal of gastroenterology : WJG》2021,27(12):1132-1148
Localized gastric amyloidosis (LGA) is a rare disease characterized by abnormal extracellular deposition of amyloid protein restricted to the stomach and it is confirmed by positive results of Congo red staining. Over decades, only a few cases have been reported and studies or research focusing on it are few. Although LGA has a low incidence, patients may suffer a lot from it and require proper diagnosis and management. However, the pathology of LGA remains unknown and no overall review of LGA from its presentations to its prognosis has been published. Patients with LGA are often asymptomatic or manifest atypical symptoms, making it difficult to differentiate from other gastrointestinal diseases. Here, we report the case of a 70-year-old woman with LGA and provide an overview of case reports of LGA available to us. Based on that, we conclude current concepts of clinical manifestations, diagnosis, treatment, and prognosis of LGA, aiming at providing a detailed diagnostic procedure for clinicians and promoting the guidelines of LGA. In addition, a few advanced technologies applied in amyloidosis are also discussed in this review, aiming at providing clinicians with a reference of diagnostic process. With this review, we hope to raise awareness of LGA among the public and clinicians. 相似文献
8.
目的:分析腹腔化疗港并发症发生及相关危险因素。方法:回顾性分析我院323例放置腹腔化疗港病人的临床资料,纳入261例胃癌腹膜转移病人。分析腹腔化疗港在胃癌腹膜转移病人腹腔化疗时发生的并发症及其危险因素。结果:261例中59例(22.6%)发生化疗港相关并发症。其中,皮下积液(25例,42.4%)和化疗港感染(16例,27.1%)是发生较多的并发症。其他是港体倾斜翻转(9例,15.3%),化疗港局部切口裂开(7例,11.9%),导管堵塞(1例,1.7%),和皮下转移(1例,1.7%)。化疗港并发症发生的中位时间为化疗港放置后3.0个月。结合Clavien-Dindo分级方法,将化疗港发生的并发症分为1~4个等级。ECOG评分、血清白蛋白水平、置港流程优化及专业团队放置为化疗港并发症发生的独立危险因素(P<0.05)。ECOG评分为唯一影响并发症分级的关联因素(P<0.05)。结论:腹腔化疗港在胃癌腹膜转移病人腹腔化疗中的应用安全可行,发生并发症可控。ECOG评分、血清白蛋白水平、置港方式是否优化及是否专业团队放置为化疗港并发症发生的独立危险因素。 相似文献
9.
Eirini D. Basdeki Christiana Tsirimiagkou Antonios Argyris George Moschonis Petros Sfikakis Athanase D. Protogerou Kalliopi Karatzi 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(1):85-94
Background and aimsIncreased alcohol consumption has been associated with CVD risk. Subclinical arterial damage (SAD) precedes the onset of cardiovascular disease (CVD), and allows early identification and study of the pathophysiology of CVD. Reliable, noninvasive vascular biomarkers are available for the early detection of SAD and reclassification of CVD risk. To investigate the association of alcohol consumption with multiple SAD biomarkers and central hemodynamics in a large sample of Greek adults with CVD risk factors.Methods and resultsThis cross-sectional study was conducted with 938 participants (43.5% men) and collected data on SAD biomarkers, central hemodynamics, and dietary intake. Multiple linear regression analysis was performed according to sex after adjusting for several confounders. In men, alcohol consumption of 20–30 g/d was positively associated with mean, diastolic, and peripheral systolic blood pressure (BP). The consumption of >30 g/d was positively associated with the augmentation index. In women, no statistically significant associations were found between alcohol consumption and BP or SAD indices. No statistically significant associations were found between alcohol consumption and arterial compliance or distensibility in both sexes.ConclusionIn men even a small deviation from the current recommendation for alcohol consumption is associated with both higher BP indices and pressure wave reflections. The absence of association in women might be due to very low alcohol intake, even in the high consumption group. More studies are needed to verify our findings and establish the above associations in each sex. 相似文献
10.
Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell line were investigated, MTT, colony formation, Transwell, wound-healing, TUNEL, Comet, immunofluorescence and western blot assays were used to assess the effects of dioscin on A431 cells. The results of MTT, colony formation, Transwell and wound-healing assays revealed that dioscin suppressed proliferation, colony formation and invasion of the cancer cells. TUNEL and comet assays demonstrated that dioscin exhibited significant effects on cell apoptosis and DNA damage. Investigations into the mechanism revealed that the expression levels of phosphorylated Ataxia telangiectasia-mutated (ATM) were considerably activated by dioscin, which significantly upregulated the expression levels of p53 to activate mitochondrial apoptosis signaling. Furthermore, the expression levels of BAX, cleaved caspase-3/9 and cleaved poly (ADP-ribose) polymerase were upregulated, and the expression levels of BCL-2 were downregulated by dioscin. Additionally, dioscin markedly downregulated the expression levels of matrix metalloproteinase 2 (MMP2), MMP9, RHO and cdc42, which are all associated with tumor invasion. In addition, p53-small interfering RNA transfection experiments indicated that dioscin exhibited excellent activity against skin cancer in vitro by decreasing p53 expression. Overall, the present results suggested that dioscin inhibited skin cancer cell proliferation via adjusting ATM/p53-mediated cell apoptosis, migration and DNA damage, which should be considered as a potential option for future treatments of skin cancer. 相似文献